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Unlike single-target GLP-1 receptor agonists such as semaglutide, retatrutide is being studied for its capacity to activate three distinct metabolic hormone receptor pathways through a single molecule, a design that places it in a separate category from both mono- and dual-agonist compounds currently in clinical use
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The most commonly reported GI AEs include nausea, diarrhoea, vomiting, and constipation, which are typically mild to moderate in intensity and transient in duration [13, 38, 40,41,42,43,44,45,46, 52]
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