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Adjusting testosterone dosing doesn't change their stone risk

10.1136/bmj.l6217 222 JohnstoneN.MilesiC.BurnO.Van Den BogertB.NautaA.HartK.et al

This peroxidation occurs via two major pathways: the enzymatic pathway, mediated by lipoxygenases (LOXs), cytochrome P450 oxidoreductase (POR), and NADPH oxidases (NOXs), promotes the generation of PUFA-PL-OOHs, leading to the accumulation of reactive aldehydes, ketones, and other toxic metabolites, ultimately disrupting membrane integrity and triggering ferroptosis (Maheshwari, 2023)