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Both GLP-1R and GIPR agonists conferred robust protection against T2DM, lowered BMI, and improved insulin sensitivity, highlighting their foundational roles in systemic metabolic control

They are designed to work on the same receptors as the natural hormone but more strongly or for longer, which is why they are typically taken weekly rather than daily

There was no significant disparity in adverse reactions among the different preparations of GLP-1RA, among which the most common were gastrointestinal reactions, which mainly manifested as nausea, vomiting, and diarrhea

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