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Studies of SEMA in metabolic liver disease have shown improvement in steatohepatitis with daily administration, but the results have been less satisfactory regarding the improvement of fibrosis at stages F2F3 or F4,30 or with a weekly dose of 2.4 mg over 72 weeks.31 The results of the new phase III ESSENCE trial, evaluating SEMA 2.4 mg over 240 weeks, are highly anticipated
That glucose-lowering magnitude is clinically meaningful
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10.1186/1471-2474-12-86 21 JohannsenF.OlesenJ
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