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PRRs and their ligands Although their roles are multifaceted, PAMPs and DAMPs primarily act as Signal 0, engaging specific receptors, predominantly pattern recognition receptors (PRRs), to activate immune responses and regulate other cellular activities, such as autophagy, apoptosis, and tissue repair

Indeed, studies have demonstrated that even if long-term carnitine administration in humans increases plasma carnitine concentrations, it does not increase muscle carnitine content," the researchers noted

Altogether, extrapolating preclinical findings directly to a human setting is premature without further investigations

Evaluation of selenium, redox status and their association with plasma amyloid/tau in Alzheimer's disease