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Patients taking tirzepatide in both trials had a 1617% reduction in body weight, along with improvements in OSA-specific hypoxic burden, and high sensitivity C-reactive protein (a biomarker of systemic inflammation and cardiovascular risk) [113, 114]
This is the point where FSH, LH, estradiol, and thyroid markers give you the data to make an informed decision about whether to continue escalating, hold your dose, or modify your caloric intake to reduce the metabolic stress signal to the hypothalamic-pituitary-ovarian axis
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In animal studies, Ozempic and Trulicity increased the risk of thyroid cancer
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