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When levels dip below this threshold, it can trigger a wide range of symptoms, including: Increased body fat Reduced muscle mass and strength Fatigue and low energy levels Low sex drive and erectile dysfunction Mood swings, depression, and irritability Increased inflammation and pain sensitivity Poor sleep quality and insomnia Memory loss Hair loss ( 3 ) These factors can all contribute to or worsen joint pain, making it more difficult to move freely and comfortably

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Test Before You Start: Check estrogen, progesterone, testosterone, LH, and FSH before beginning a GLP-1 optimizing hormones may be what makes the treatment work

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a public comment period is open through June 29, 2026

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Calorie restriction stacking GLP-1 medications already reduce your appetite significantly

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