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Epithalon might correct spindle abnormalities and prevent the misplacement of CGs, which are common issues in aged oocytes

We also explored several other known regulators of PGC1 activity that are altered in response to 5FU treatment in HCT116, including NRF2, reactive oxygen species and PPAR, but none of these prevented PGC1-driven increases in mitochondrial mass

MITOCHONDRIAL ROS GENERATION AND DEFENSE Reactive oxygen species can be generated in several intracellular sites, including cytosol, peroxisomes, plasma membrane, and ER

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