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Hydrochlorothiazide is not an aldosterone antagonist, and its main action is independent of carbonic anhydrase inhibition
The standard protocol begins at 2.5 mg weekly and rises in 2.5 mg steps every four weeks, only if the patient is tolerating the previous dose
Moreover, patients with acromegaly treated with either GH-receptor antagonists or somatostatin analogues represent a peculiar setting that need to be studied in depth to define safety and efficacy of both drug classes and their interaction with the GH/IGF-1 axis
Tirzepatide is a modern medication used to support weight loss and manage metabolic health
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