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doi: 10.1002/cam4.871
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Another mechanism may involve activation of sirtuins, especially sirtuin1 (SIRT1) and its transcriptional co-factor peroxisome proliferator-activated receptor- coactivator 1 alpha (PGC-1), although few data of human studies are available 26
Sobue et al., 2023) and activated microglia has been reported to surround the protein depositions (Heneka et al., 2013), contributing to the spread of A plaques (Rani et al., 2023)
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