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Long-term use raises concerns about possible liver and kidney damage, though specific data on how often this happens remains limited

Patient-derived xenograft The PDX experiment was approved by the Animal Ethical and Welfare Committee of the Sixth Affiliated Hospital, Sun Yat-sen University (Ethical code: IACUC-2021011501)

Preclinical toxicology studies have not identified acute toxicity at doses far exceeding the effective range

Evidence for a 'paravascular' fluid circulation in the mammalian central nervous system, provided by the rapid distribution of tracer protein throughout the brain from the subarachnoid space