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If GLP-1 drugs prove effective in reducing cravings or reshaping reward response, they could become part of a broader toolkit for addressing: Alcohol use disorder Nicotine dependence Stimulant addiction Binge eating disorder Impulse control disorders However, experts emphasize that GLP-1 medications are not a stand-alone cure for addiction

Expected gastrointestinal side effects that typically do not require urgent intervention include: Sulphur burps without severe pain Mild to moderate nausea, particularly after meals Occasional loose stools or mild constipation Feeling of fullness or early satiety Mild, intermittent abdominal discomfort These symptoms, whilst unpleasant, generally improve with time, dietary modification, and symptomatic management

Amgen anticipates potential sales erosion in 2025 due to biosimilar competition, particularly in the second half of the year

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