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Whilst no definitive causal link has been established, caution is warranted in those with previous episodes
Liu J, Yao S, Wang M, et al
Some of these adverse effects reported were Toxic Epidermal Necrolysis (a rare but life-threatening skin condition characterized by painful blisters and large areas of skin peeling), air embolism, thyroid dysfunction, and liver, kidney, and neurologic toxicity (The dark side of skin lightening- PubMed) With the proliferation of med-spas in an unregulated fashion, there is a risk of inadequately trained or untrained people giving IV injections in a non-sterile way, which can lead to sepsis and transmission of infections like HIV and hepatitis
The body preferentially uses adipose stores rather than breaking down muscle protein for fuel
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