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Why This Matters: Understanding What Is Really Happening When GLP-1 therapy begins, multiple systems adjust simultaneously: Appetite signals are suppressed, leading to lower calorie intake Insulin secretion becomes more precise and glucose-dependent Blood sugar variability decreases Fat stores begin to supply a greater proportion of daily energy This shift is metabolically beneficial, but it requires adaptation

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doi: 10.1016/j.diabres.2024.111617, 133 SikiricaM

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