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Many studies have shown a U- or J-shaped relationship between BMI and mortality, where lower and higher BMI are associated with increased mortality risk compared to normal weight BMI levels (defined as a BMI between 18.5 to 25 kg/m)

10.1002/jcsm.13722 J

Therefore, processes such as hypoxia and hyperoxia can disrupt oxidative balance and ultimately induce oxidative stress [12, 13], with ROS being one of the main participants [14]