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Skin care, energy-based treatments, and non-surgical options may improve mild texture or laxity in select patients, but they are not designed to remove significant folds of hanging skin

To improve transparency, an adapted PRISMA-style flow diagram documenting identification, screening, eligibility assessment, de-duplication, and selection of the RCT evidence base and the proof-of-concept Bayesian subset is provided in the Supplementary Appendix Figure 1, together with details of the search strategy, screening process, and data extraction

The downside is a larger draw volume for the same dose

These inconsistent findings could be attributed to differences in the duration of treatment and the manner in which rates of EE are presented