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They include increased blood pressure, tachycardia (heart rate over 100 beats per minute), pulmonary hypertension, disease of the heart valves, or even events related to ischemia (loss of blood flow) to the heart or other organs
Bridging these gaps will require the integration of human-relevant models such as ovarian organoids and microphysiological systems, the development of validated biomarkers and potency assays, and the execution of large-scale, well-controlled clinical trials with long-term follow-up
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Molecular docking Molecular docking of ursolic acid, oleanolic acid and betulinic acid with FXR was carried out using AutoDock QVina-W
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