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And so, the system is already there to make these peptides functional. This delivery platform also allows the natural versions of these peptides to be used, potentially lowering the risk of side effects, he notes

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413 Partial ablation of astrocytes in the prefrontal cortex of healthy rats (by injection of gliotoxin L--aminoadipic acid) resulted in the development of depressive-like behaviours, whereas injection of neurotoxin ibotenate did not have such an effect