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Activation of these sensors initiates checkpoint cascades, most notably ATMChk2 and ATRChk1, which coordinate cell cycle arrest, DNA repair pathway selection and apoptosis or senescence when repair fails
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In the gas-fluid organoids derived from colon cancer, the efficacy of 5-FU, irinotecan, and oxaliplatin is enhanced by hedgehog signaling inhibitors through the suppression of GLI-1 expression, thereby reducing drug resistance [234]
Overexpression of glutathione S-transferase pi enhances the adduct formation of [PMID: 10630679] Laboratory literature summary: Overexpression of glutathione S-transferase pi enhances the adduct formation of cisplatin with glutathione in research subjects oncology
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