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When activated, the mast cells in the skin release mediators (histamines, tryptase, TNF-alpha, CXCL9, etc.) that cause inflammation, flushing, itching, or burning.[ref] Related article: Rosacea, underlying causes, genetic susceptibility Dermatographism and mast cell activation syndrome: In a survey of mast cell activation syndrome, dermatographism was found in 89% of the patients.[ref] Dermatographism is when you get welts or raised red lines when you scratch your skin lightly

Randomized clinical studies in acute urticaria have shown diphenhydramine effectively reduces itch and wheal formation, supporting its role as short-term rescue therapy

Some anticoagulant medications, including unfractionated heparin, increase APTT, reflecting prolongation of the time needed for clot formation

Injectable GHK-Cu just aren't that practical for most people evaluating GHK-Cu injection vs topical options