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A broader review of glutathione for skin reached a similar, cautious conclusion, noting limited high-quality evidence overall (a narrative review of the safety and efficacy of glutathione supplementation for skin lightening)

Metabolic analysis Oxygen consumption rate (OCR) and extracellular acidification rate (ECAR) were measured with a 24-well XF Extracellular Flux Analyzer (Agilent Technologies) and Seahorse Wave Controller Software (Agilent Technologies), according to the manufacturers instructions

Glutathione oral supplements Research on oral glutathione supplements is mixed, largely because the antioxidant is poorly absorbed during digestion

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