How Does the Transsulfuration Pathway Support Liver Detoxification
10.1016/j.freeradbiomed.2015.05.034 41 CantnI.AkhtarS.GavalasN
Use caution if you have autoimmune disease, bleeding disorders, active infection, cancer history, or if you take anticoagulants, immunosuppressants, or systemic steroids

Applying vitamin C to your skin may reduce hyperpigmentation by interfering with an enzyme called tyrosinase, which is responsible for the production of melanin, a natural skin pigment ( Moreover, vitamin C acts as a brightening agent and can reduce the appearance of darkened spots without changing the natural color of your skin ( Some human studies that combine topical vitamin C with iontophoresis an electrical gradient applied to the skin found significant reductions in hyperpigmentation ( Though this method is promising, iontophoresis increases vitamin C absorption into your skin, meaning that topical application of vitamin C alone may not yield the same results ( Furthermore, most related studies use vitamin C in combination with other anti-hyperpigmentation ingredients like alpha-hydroxy acids, making it hard to determine the specific effects of the vitamin