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Discovered in 1888, Glutathione (GSH) is an important antioxidant in plants, animals, fungi, and some bacteria
Recently it was shown that a new class of N-acyl amides is produced by the microbiota, and target GPCRs expressed by the enteroendocrine cells, modulating GLP-1 expression and overall glucose metabolism
Hereby, the suppression of inflammatory injury with GLP-1RAs treatment can be eliminated by 3-methyladenine/the mitochondrial kinase (PINK1) siRNA [141]
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