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Significant appetite reduction
The administration of GLP-1RA or exendin-4 to rats fed a high-fat diet resulted in an increase in the OPG/RANKL ratio and a reduction in the degree of bone loss
Quick Answer: Flu-like symptoms are not listed as common adverse effects in FDA prescribing information for tirzepatide, though some patients report fatigue and systemic symptoms that may be related to dehydration or metabolic adaptation
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