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Given that PKA-mediated signaling is required for glucose-stimulated insulin release, this could be perceived as a contradiction between this mechanism and reports of enhanced insulin secretion under these conditions 75

Abbreviations AhR: Aryl hydrocarbon receptor AMPK: AMP-activated protein kinase APC: Antigenpresenting cell CAR-T: Chimeric antigen receptor T cell CCA: Cholangiocarcinoma CRC: Colorectal cancer CTL: Cytotoxic T lymphocyte CXCR: C-X-C chemokine receptor DCs: Dendritic cells DCA: Deoxycholic acid FFAR2: Free fatty acid receptor 2 FMT: Fecal microbiota transplantation GPCR: G protein-coupled receptors HCC: Hepatocellular carcinoma ICB: Immune checkpoint blockade ICI: Immune checkpoint inhibitor IDO: Indoleamine 23dioxygenase ILA: Indole3lactic acid iNKT: Invariant NKT IPA: Indole3propionic acid IPyA: Indole3pyruvic acid LCA: Lithocholic acid LPS: Lipopolysaccharide MAMPs: Microbeassociated molecular patterns MDSCs: Myeloidderived suppressor cells NK: Natural killer cell NKT: Natural killer T cell NOD: Nucleotidebinding oligomerization domain NSCLC: Nonsmall cell lung cancer PCa: Prostate cancer PDAC: Pancreatic ductal adenocarcinoma PPAR: Peroxisome proliferatoractivated receptor PRR: Pattern recognition receptor ROS: Reactive oxygen species SBAs: Secondary bile acids SCFAs: Shortchain fatty acids STAT3: Signal transducer and activator of transcription 3 TAMs: Tumorassociated macrophages TCR: T-cell receptor TLCA: Taurolithocholic acid TLR4: Tolllike receptor 4 TMAO: Trimethylamine Noxide TME: Tumor microenvironment Tregs: Regulatory T cells TNBC: Triplenegative breast cancer UDCA: Ursodeoxycholic acid 3-IAA: Indole3acetic acid References Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, et al