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An estimated 400 million people are affected by G6PD deficiency globally, and ~160 identified amino acid missense variants cause G6PD deficiency, which is more prevalent in the African continent, Middle East, and South and Southeast Asia

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showed that topical glutathionecyclodextrin (GSH-CD) increased intracellular GSH in mononuclear and red blood cells, decreased malondialdehyde (MDA), and significantly upregulated immune cytokines including IL-2, IFN-, IL-12p70, and TNF-