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The main disadvantages are the need for weekly injections, potential GI side effects (nausea, vomiting, diarrhea), and cost
Animal model studies have suggested that GLP-1RAs may cause pancreatitis and exocrine dysplasia, but in the large RCTs and a meta-analysis, GLP-1RAs did not increase the risk of pancreatitis or pancreatic cancer [82,83]
All oral mucosal surfaces available for inspection should be visualized
Discontinue and reassess if shedding seems disproportionate to expected adjustment
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