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BOOMERANG HUNGER The final, most important, pitfall is preventing the rebounding hunger that happens upon abrupt withdrawal of these medications particularly once up to higher doses

This strategy has been exploited in the long-acting GLP-1RA semaglutide (Novo Nordisk), for instance, which was approved for treatment of T2DM in 2017, and for treatment of obesity in 2021, and has since then become the most prescribed GLP-1RA 92

However, I felt pretty drowsy after just one capsule, making this a better choice for unwinding in the evening rather than before driving or operating heavy machinery

It's not appropriate for all women, for example, it's generally not recommended for women with PCOS, who already have elevated androgen levels