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DM4 has the ability to induce a potential resistance mechanism
The goal is not to maintain exact weight
When we eat, the gastrointestinal system produces a variety of hormones in response, that go on to signal satiety to the brain
Ex-4 exerts regulatory control over the PI 3 K/Akt/Foxo1 pathway, impeding the nuclear entry of Foxo1 and consequently enhancing the expression of insulin gene transcription factors PDX-1 and MafA
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