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Key findings from SURMOUNT-5 at 72 weeks: Tirzepatide produced a mean body weight reduction of 20.2% compared to 13.7% with semaglutide

A systematic review and meta-analysis published in Reviews in Endocrine and Metabolic Disorders confirmed it: tirzepatide reduced high-sensitivity C-reactive protein (hsCRP) by a mean difference of -32.9 and interleukin-6 (IL-6) by -17.8 compared to placebo across multiple clinical trials

Interestingly, these residues of the GLP-1R are crucial for intracellular signaling and are responsible for insulin exocytosis