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Perk is essential for translational regulation and cell survival during the unfolded protein response
As we age, levels of both NAD+ and glutathione decline, leading to reduced cellular efficiency and increased vulnerability to damage (Braidy et al., 2019)
Ideal for systemic distribution or when local injection seems impractical
This includes increased production of glycolytic end products and elevated levels of key glycolytic enzymes such as hexokinase 2 (HK2), 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3), and pyruvate kinase M2 (PKM2) (Lan et al., 2016)
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