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While the National Center for Complementary and Integrative Medicine notes that much of the research into its effects is preliminary, we do have some promising studies to support its adaptogenic function.34 For example, a 2008 pilot study, which administered 340mg of rhodiola extract to participants with generalized anxiety disorder over ten weeks, showed "significant decreases" in mean scores on the Hamilton Anxiety Rating Score.35 A later study from 2015 saw "significant improvements in total mood" and a "significant reduction in self-reported anxiety, stress, anger, confusion, and depression" with a 400mg dose.36 Codeage Meditate Vitamins+ is the only one of our recommended cortisol-reducing supplements to include rhodiola in its formulation, though it's obscured behind a proprietary "Deep Blue Mind Enhancing Blend." The blend totals 500mg, so the quantity of rhodiola is unlikely to align with clinically relevant doses, but the botanical may still play a valuable supporting role alongside the other ingredients to help reduce stress and overall cortisol

Glutathione inhibits tyrosinase through copper chelation at the active site, pheomelanin pigment shift, and ROS-mediated MITF suppression simultaneously