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Notably, patients with reduced ejection fraction had higher absolute event rates, meaning the medication prevented more events in this higher-risk group

The substantial reduction in systemic inflammation, as indicated by high-sensitivity C-reactive protein (hs-CRP) levels, alongside improvements in overall metabolic health, such as weight loss and glycemic control, represents significant systemic alterations that may indirectly benefit the brain by mitigating chronic inflammatory stimuli and enhancing cerebrovascular health

In poplar GSTFs, nearby hydroxylated residues present in the active site signature (often STxT) could be involved in GSH activation (Pgeot et al., 2017)