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Eur Heart J 2025;46:3685-3713 Erratum in: Eur Heart J 2025;46:4791

My clothes are fitting the way they should, and Im losing the extra fluff around the muscle

Once the body is in oxidative stress, or if there are a large number of electrophiles or cytotoxic agents, Nrf2 is released from the Keap1 binding site and rapidly transferred to the nucleus, subsequently interacting with the antioxidant response element (ARE) in the promoter region of the target gene and then activates the transcriptional pathway to balance oxidative stress and maintain cellular redox homeostasis (Zhang, 2006)

Patients can be confident that the drug will work as intended, based on established research