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Anti-NASH compounds tested on the MPS NASH model demonstrated efficacy on both inflammasome and fibrosis biomarkers, with most significant changes observed following SCD1 inhibition and CCR2/5 inhibition but limited effects of ASK-1 inhibition
Key among the identified genes are TP53, VEGFA and PTGS2 (195), which have been highlighted as potential markers for ferroptosis within the context of schizophrenia
This enzyme is key for processing amino acids, which are protein building blocks
Membrane damage during ferroptosis is caused by oxidation of phospholipids catalyzed by the oxidoreductases POR and CYB5R1
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