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Higher doses tend to produce faster initial results, but the trajectory of weight loss usually follows a similar curve regardless of starting dose, with the most dramatic losses occurring in the first three to six months

The Research Gap Phase I safety trials have been conducted but results were never published despite completed status

"Some people will say things like, 'Oh, when I started regaining weight, it seemed like I just smell food, and I gained more weight.' That's an exaggeration, of course, but it can certainly feel that way given the pace of how quickly some people can regain weight." In addition, as with weight loss, many variables affect weight gain, some of which we can control, some of which we can't

Finally, there is a suggestion that selenium is particularly central in influencing the action of the transcription factor TGF beta [18, 19, 20], helping to maintain gut barrier integrity and thus enhancing the differentiation of T-regulatory cells and reducing inflammation by decreasing IL-6 and enhancing IL-10 levels [21]