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Another phase 2 trial using a higher dose of mazdutide for obesity (9 mg) is currently ongoing with a press release revealing a placebo-adjusted WL of 15.4% after 24 weeks [71]
This program aims to support the preservation and growth of lean muscle, maintain or boost metabolism, and foster positive dietary habits that encourage a lifelong healthy relationship with fitness and well-being
However, no single GLP-1 is definitively 'easiest' for everyone, and careful dose titration alongside dietary adjustments can significantly improve tolerability across all agents
Eli Lilly might have solved that problem with orforglipron, a small-molecule formulation.
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