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Timing-dependent effects primarily influence circadian phase alignment, sleepwake timing, and synchronization between central and peripheral clocks, whereas dose-dependent effects are more closely related to signal amplitude, antioxidant capacity, and cytoprotective actions
Forced G1-phase reduction alters mode of division, neuron number, and laminar phenotype in the cerebral cortex
Reconstitution: Bring vial and diluent to room temperature
The two major limitations of this trial are that the treatment duration was only for 28 d and the subjects were under generally excellent metabolic control
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