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B12 shots can be especially helpful if you are older, do not eat animal products, have conditions that impact nutrient absorption, or take medications that interfere with nutrient absorption
An early trial also measured weight loss at 0.05 mg daily, nominally about 0.35 mg per week, confirming activity in the low-dose zone without testing a weekly microdose protocol. The 2.4 mg maintenance dose sits on the shoulder of the effect curve rather than at a hard ceiling
The evidence base is preclinical, built on cell and mouse models
In 2023 the FDA put them on a list of substances too risky to compound at all
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