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High-resolution approaches, including super-resolution microscopy, electron tomography, and emerging ovarian three-dimensional imaging techniques, can be applied to age-stratified ovarian samples to quantitatively map changes in mitochondria-ER, mitochondria-lysosome, mitochondria-peroxisome, and mitochondria-lipid droplet contact sites in oocytes and granulosa cells

The neuronal loss and atrophy were particularly evident in the CA1 region of the hippocampus and layers II-III of the cerebral cortex