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Stromal-epithelial interactions during embryogenesis may influence the development of distinct melanocyte subpopulations that differ in anatomic distribution and the potential to evolve into various types of melanocytic proliferations (13,14,15,16,17,18 and 19), features that underscore the heterogeneous nature of malignant melanoma with respect to the different site-dependent features
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Biological tests were conducted both in vitro and in vivo
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