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CJC-1295 appears to be a synthetic analog made of the first 29 amino acids from the GHRH sequence, which has additional modifications, including the replacement of four amino acids in its structure and the attachment of a Drug Affinity Complex (DAC) to potentially extend the pharmacokinetics of the peptide

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To explore the functional role of FOXO4 in senescence, its expression was silenced using siRNA in TM3 Leydig cells prior to H2O2-induced senescence