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Therapeutic potential of glutathione-enhancers in stress-related psychopathologies

Acknowledgements We thank Eri Shibata for providing excellent technical assistance

This review synthesizes emerging insights into lactates multifaceted roles and discusses promising therapeutic strategies targeting lactate metabolism, transport, and downstream signaling pathways, with an emphasis on candidates advancing toward clinical translation

Here, we used phage-assisted evolution to reprogram botulinum neurotoxin serotype X proteases to cleave and activate procaspase-1 and gasdermin D, key effectors of inflammatory cell death