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The SURMOUNT-1 trial found that visceral fat mass decreased by 40.1% with tirzepatide compared to just 7.3% with placebo
The prevalence of comorbidities was as follows: 51.1% of patients with hypertension, 50% with diabetes mellitus, 5.2% with psychoactive substance use, and 0.5% experiencing problems related to housing and economic circumstances
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Both are injectable peptide-based therapies targeting multiple hormonal pathways cagrilintide as a long-acting amylin analogue, and retatrutide as a triple receptor agonist acting on GLP-1, GIP, and glucagon receptors
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