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When you stop taking creatine, your muscle creatine stores gradually deplete over 46 weeks, leading to temporary water weight loss, reduced muscle fullness, and a mild decline in high-intensity performance but not a loss of actual muscle mass if you continue training

[19] Muscle Amino Acid Transport Recent research has shown that glutamic acid can enhance the expression of amino acid transporters in muscle tissue, potentially improving the delivery of other muscle-building amino acids

For example, Wegovy is specifically FDA-approved for weight management in adults with obesity or overweight conditions