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This triple-agonist approach, targeting GLP-1, GIP, and glucagon receptors, produced the most dramatic weight loss results seen in any Phase 2 obesity trial
10.1016/S0015-0282(01)01816-7 124
Nature Communications (2025) 8
This shows that care must be taken in interpreting blood measurements, and that ideally one would like to conduct experiments in which both intracellular and extracellular concentrations are measured
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