Beyond its primary location in pancreatic -cells, GLP-1 receptor (GLP-1R) has been identified in various other tissues, including the gastrointestinal tract, lung, kidney, heart, bone, central nervous system, liver, and adipose tissue (Bu et al., 2024)
Tirzepatide activates two pathways rather than one, sometimes producing different gastrointestinal responses in patients whose baseline digestion is already altered
The outermost layer of the epidermis is the stratum corneum (SC), which consists of 1520 layers of non-viable, flattened corneocytes embedded in a lipid matrix, and can thicken from 10 to 15 m to 40 m under moist conditions [221, 222]
These findings further underscore the notion that GLP-1R plays pivotal roles in both diseases