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For example, 2D cultures only allow interactions with neighboring cells and the formation of cell-ECM adhesions on the substrate side in the horizontal plane, whereas in 3D culture, cells are capable of forming adhesions on all sides in a dynamic way [239]

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doi:10.1038/s41574-019-0176-8 3

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A nutrient-rich diet packed with vitamins, minerals, and antioxidants enhances skin brightness, reduces pigmentation , and prevents premature aging

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This positions FOXO4-DRI within advanced molecular longevity research rather than endocrine or metabolic peptide categories

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