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In cancer cell lines, the mTORC1 signal can also promote de novo lipid synthesis through the sterol responsive element-binding protein (SREBP) transcription factors, which induce the expression of metabolic genes responsible for lipid biosynthesis, including fatty acid synthase (FASN) (Duvel et al., 2010)

Unlike topical self-tanners (which work through surface chemistry rather than melanogenesis) or topical melanocortin formulations (which have limited dermal penetration), intranasal delivery achieves systemic distribution and authentic eumelanin production

Changes in Body Composition Over 8 Years in a Randomized Trial of a Lifestyle Intervention: The Look AHEAD Study. Obesity

10.1111/j.1440-1681.1997.tb02718.x 130 MesensN.SteemansM.HansenE.VerheyenG