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In an in vivo study, the acute treatment with GLP-1 in female rats resulted in the increase of the amplitude of the preovulatory LH surge, likely by the activation of the kisspeptin hypothalamic system, a key regulator of the pulsatile release of GnRH from GnRH neurons [35]
second-generation clocks that predict mortality/morbidity risk (PhenoAge and GrimAge, including a principal-component version of GrimAge denoted PCGrimAge)
Women of childbearing potential should discuss contraception, as tirzepatide can decrease exposure to oral contraceptives, requiring backup contraception for 4 weeks after initiation and after each dose increase
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